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After the industrial revolution, urban growth has been increasing, especially with technological advances. Urbanization is accelerating environmental pollution and also affects climate significantly because of land use or land cover changes. In this study, the Hydrological Simulation Program-Fortran (HSPF) model developed by the United States Environment Protection Agency (USEPA) is used for modeling the impervious areas of Eskişehir which is located in the Porsuk Stream Watershed in Inner Anatolia, Turkey. Effects of impervious areas of Eskisehir on the Porsuk Stream pollution between 1975 and 2010 have been investigated. Important water quality parameters like nitrate, orthophosphate, sediment, chloride, and total coliform are modeled. Impervious land segments have been found to be affecting all parameter concentrations and also surface flows significantly as determined using the t test with a confidence level of 95 %.