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Numerical studies on impacts of landscape fragmentation due to land use and land cover change (LUCC) on precipitation fields over the Ji-Paraná basin in the Amazon region are carried out using atmospheric Eta model. Experiments consider historical data about LUCC over the basin from 1978 to 2000 and compare simulations under LUCC conditions with simulations under pristine conditions. In agreement with previous observational studies, model results do not show statistically significant impacts on precipitation in the region. Results indicate that variability in precipitation in this region is mainly controlled by large-scale atmospheric characteristics and soil moisture conditions. However, some limitations are identified in the model simulations, mainly associated to the diurnal cycle of precipitation.