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Since urban areas with high air pollution are known to have higher mortality rates compared to areas with less air pollution, accurately understanding and predicting the distribution of particulate matter (PM) in cities is important for urban planning policies that seek to emphasize the health of citizens. Therefore, this study aims to investigate the relationship between PM and land use in metropolitan cities in South Korea using the land-use regression model. We use daily data from the air quality monitoring stations (AQMS) in seven cities in South Korea for the year 2018. For analysis, K-means clustering is employed to identify the land-use pattern surrounding the AQMSs and two log-lin regression models are used to investigate the effects of each land-use type on PM. The findings show a statistically significant difference in PM concentration and variability in the business, commercial, industrial, mixed, and high-density residential areas compared to parks and green areas, and that PM concentration and variability were less in mixed areas than in single land use, thus verifying the effectiveness of a mixed land-use planning strategy. Moreover, microclimatic, seasonal, and regional factors affect PM concentration and variability. Finally, to minimize exposure to PM, various policies such as mixed land use need to be established and implemented differently, depending on the season and time.