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An intensive process of land deterioration of some regions in Uzbekistan including the Aral Sea basin has led to a significant increase in soil salinity levels and consequently to a considerable reduction of total fertile soil area, as these lands are of little use for plant growth. The area is estimated to be more than 1.4 million ha of seabed. As a result, there was an immediate need to cultivate new crops capable of stopping the movement of sands and the enlargement of saline soils. Safflower (Carthamus tinctorius) is considered to be a moderately salt‐tolerant crop and, as such, one of a few crops well suited to the cropping systems of salt‐affected soils. It is used in Uzbekistan as a reserve crop when the culture of the main crop fails. In spite of the great economic importance of this oil, there is almost no available information in the literature on the effect of salinity on oil quality and its chemical ingredients. The purpose of the present study was to determine, in greenhouse and field experiments, how irrigation with saline water would influence content of oil, lipids and other lipophylic components in safflower. We found that irrigation of safflower with moderate concentrations of saline water seems feasible, as far as oil and lipid composition is concerned. Consequently, safflower might be a potential crop for lands of little use for plant growth in Uzbekistan or other similar sites in the world.