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After reviewing the main causes and effects of land degradation and erosion in the uplands of mainland Southeast Asia, this chapter presents several case studies of recent land-use changes governed by economic, political and institutional transitions, the expansion of teak and rubber tree plantations in northern Laos and southwest China, respectively, and of monocropping coffee in the Central Highlands of Viet Nam. We explain how these environmental disturbances are altering water and soil resources across different geographic scales, from the agricultural plot to the headwater catchment. Examples of coping strategies combining field trials and participatory approaches are illustrated with several case studies taken from research for development activities conducted in Cambodia, Laos, Viet Nam and the Yunnan Province of China. These activities were part of the CGIAR Research Program on Integrated Systems for the Humid Tropics (Humidtropics) in the Central Mekong Action Area. We propose solutions for sustainable agricultural intensification to diversify income, improve dietary diversity and improve natural resource management. The accomplishment of these objectives requires longterm involvement with ethnic minority communities that have been the particular focus in the target areas. The three-anda-half-year lifespan of Humidtropics in the Mekong region was a short period. It would require extension to maintain the carefully built and nurtured relationships with local implementation partners and local farming communities, and reach its full promise.