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Nigeria is the second largest poultry industry in Africa, with its poultry industry the most commercialized livestock sub-sector. Despite its significance, the farmers still experience economic losses due to disease outbreaks. Hence, the application of standard Health Management Practices (HMPs) is very important, as these practices improve the welfare of animals and increase animal production and farmers’ income. This paper examined the determinants of HMP’s utilization and its effect on poultry farmers’ income in Ondo State, Nigeria. We used multistage sampling procedures to select 120 respondents who provided data for the study. The study used Generalized Poisson Regression (GPR) and Conditional Quantile Regression (CQR) models to estimate the determinants of HMP’s utilization intensity, and its heterogeneous effects on farmers’ income, respectively. The results revealed that the HMP’s utilization intensity was significantly driven by variables such as education, training, experience, land ownership, stock size, mortality rate, and production system. In addition, HMP’s utilization had significant heterogeneous effects on farmers’ income. Therefore, the government and other developmental agencies should promote HMP’s utilization through the provision of poultry-based skills acquisition and vocational education.