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System thinking and integrated research are widely applied approaches in environmental management, often facilitating the organization of information from different levels and sources. They are here applied to support the review of (1) political and management instruments and (2) elements that characterize the Bahia de Cádiz Nature Park (Spain). The latter objective is sustained by the DPSIR (Driver-Pressure-State-Impact-Response) framework. A first DPSI conceptual map offers a broader view of the park capturing a range of elements that act at global, national and regional levels. Next, through expert consultation, prioritized DPSI issues describing the current situation of Bahia de Cádiz Nature Park are highlighted. A second DPSI map is designed to explore specific land-use and land-cover changes and their effects on the park’s ecological integrity, offering a greater level of detail. ‘Responses’ are discussed separately, through a review of most recent response actions that have originated at various levels, and future ones proposed by the park’s management. The framework proves to be appropriate to identify elements from both social and environmental dimensions, but excludes global-scale elements that do not fit the scope of this analysis. The review hopes to support future integrated research initiatives, involving in-depth analysis though the use of tools as are indicators or models.