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In recent decades, the problem of environmental quality and environmental safety at global, regional, and local levels has been an increasingly pressing issue. The intensive development of Siberian natural resources has resulted in the serious deterioration of the natural environment in a region which had previously had almost escaped anthropogenic impact. There are some peculiar features here associated with both specific natural conditions and types of anthropogenic influence. This paper presents data on the pollution of the environment, land degradation, and natural disasters. Key actions are identified to reduce environmental hazards in Siberia. An attempt is made to provide an integrated assessment of the environmental safety of Siberia.