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QUESTION: The decline and loss of perennial vegetation in dryland ecosystems due to global change pressures can alter ecosystem properties and initiate land degradation processes. We tracked changes of perennial vegetation using remote sensing to address the question of how prolonged drought and landâuse intensification have affected perennial vegetation cover across a desert region in the early 21st century? LOCATION: Mojave Desert, southeastern California, southern Nevada, southwestern Utah and northwestern Arizona, USA. METHODS: We coupled the ModerateâResolution Imaging Spectroradiometer Enhanced Vegetation Index (MODISâEVI) with groundâbased measurements of perennial vegetation cover taken in about 2000 and about 2010. Using the difference between these years, we determined perennial vegetation changes in the early 21st century and related these shifts to climate, soil and landscape properties, and patterns of land use. RESULTS: We found a good fit between MODISâEVI and perennial vegetation cover (2000: R² = 0.83 and 2010: R² = 0.74). The southwestern, far southeastern and central Mojave Desert had large declines in perennial vegetation cover in the early 21st century, while the northeastern and southeastern portions of the desert had increases. These changes were explained by 10âyr precipitation anomalies, particularly in the cool season and during extreme dry or wet years. Areas heavily impacted by visitor use or wildfire lost perennial vegetation cover, and vegetation in protected areas increased to a greater degree than in unprotected areas. CONCLUSIONS: We find that we can extrapolate previously documented declines of perennial plant cover to an entire desert, and demonstrate that prolonged water shortages coupled with landâuse intensification create identifiable patterns of vegetation change in dryland regions.