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Estimation of land use during the Holocene is crucial to understand impacts of human activity on climate change in preindustrial period. Until now it is still a key issue to reconstruct amount and spatial distribution of prehistoric land use due to lack of data. Most reconstructions are simply extrapolations of population, cleared land amount per person and land suitability for agriculture. In this study, a new quantitative prehistoric land use model (PLUM) is developed based on semi-quantitative predictive models of archeological sites. The PLUM is driven by environmental and social parameters of archeological sites, which are objective evidences of prehistoric human activity, and produces realistic patterns of land use. After successful validation of the model with modern observed data, the PLUM was applied to reconstruct land use from 8 to 4ka B.P. in Yiluo valley, one of the most important agriculture origin centers in northern China. Results reveal that about 2–9% of land area in the valley was used by human activity from 8 to 4ka B.P., expanding from gentle slopes along the river to hinterlands in middle and lower parts of the valley. The land cover was affected by increasing agricultural land use during the middle Holocene.