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The purpose of this research was to determine the total average annual deforestation rate and annual percentage change for the period 1990-2008, in order to establish its relationship with landscape fragmentation in two areas of ecological interest in the Province of Manabí, Wildlife Refuge Coastal Marine Pacoche and 1 500 km2 of territory in the central-north of Manabí, between the cantons Flavio Alfaro, Chone and El Carmen. For this spatial metrics based on official cartographic map information Historical Deforestation of the Ministry of Environment of Ecuador (2012), for it was made use of a GIS was used. For this period, a total deforestation of 16,16 ha / year with an annual deforestation rate of -0,87% for Pacoche and the central-north obtained deforestation was 1 015,00 ha / year and an exchange rate of -0,43%.